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Abstract
prepared from 1,3,4-thiadiazole derivative with a terminal primary amine group and was used to
synthesize a Schiff base (6) by interaction with 5-chloro salicylaldehyde and using ethanol as a
solvent. After that, it was able to prepare numerous chemical compounds utilizing the Schiff base.
Which contains a C=N group with (2-aminobenzoic acid, 2-mercaptobenzoic acid, valine, alanine,
and sodium azide) to prepare hydroqinazoline (6a), thiazinone derivative (6b), and imidazolidine
derivatives, (6c,6d). TLC follows these reactions and Melting points for derivatives were
measured. These compounds were determined by 13C-NMR, 1H-NMR, and FT-IR spectra, along
with studying the biological activity of the prepared derivatives.
Keywords
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References
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References
Omar A. Review article; anticancer activities of some fused heterocyclic moieties
containing nitrogen and/or sulfur heteroatoms. Al-Azhar Journal of Pharmaceutical Sciences.
;62(2):39–54.
Aljamali NM. Survey on methods of preparation and cyclization of heterocycles.
International Journal of Chemical and Molecular Engineering. 2020;6(2):19–36p.
Wojaczyńska E, Steppeler F, Iwan D, Scherrmann MC, Marra A. Synthesis and
applications of carbohydrate-based organocatalysts. Molecules. 2021;26(23):7291.
Pérez‐Mayoral E, Godino‐Ojer M, Pastrana‐Martínez LM, Morales‐Torres S, Maldonado
Hódar FJ. Eco‐sustainable Synthesis of N‐containing Heterocyclic Systems Using Porous Carbon
Catalysts. ChemCatChem. 2023;15(23):e202300961.
Sahu S, Sahu T, Kalyani G, Gidwani B. Synthesis and evaluation of the antimicrobial
activity of 1, 3, 4-thiadiazole analogues for potential scaffold. J Pharmacopuncture. 2021;24(1):32.
Abu-Hashem AA, Al-Hussain SA. Design, synthesis of new 1, 2, 4-triazole/1, 3, 4
thiadiazole with spiroindoline, imidazo [4, 5-b] quinoxaline and thieno [2, 3-d] pyrimidine from
isatin derivatives as anticancer agents. Molecules. 2022;27(3):835.
Raczuk E, Dmochowska B, Samaszko-Fiertek J, Madaj J. Different Schiff bases—
structure, importance, and classification. Molecules. 2022;27(3):787.
Gopalakrishnan AK, Angamaly SA, Velayudhan MP. An Insight into the Biological
Properties of Imidazole‐Based Schiff Bases: A Review. ChemistrySelect. 2021;6(40):10918–47.
Boulechfar C, Ferkous H, Delimi A, Djedouani A, Kahlouche A, Boublia A, et al. Schiff
bases and their metal Complexes: A review on the history, synthesis, and applications. Inorg Chem
Commun. 2023;150:110451.
Qadir T, Amin A, Sharma PK, Jeelani I, Abe H. A review on medicinally important
heterocyclic compounds. Open Med Chem J. 2022;16(1).
Ali L, Adnan S. Synthesis and Characterization of New Diazo Derivatives, and Study of
their Biological Activity. International Journal of Drug Delivery Technology. 2022;12(1):331–6.
Aldujaili RAB, Talib RN, Alhasan AAY. The spectral study and biological activity for
azo-shiff bases derivatives containing pyrimidine ring. Res J Pharm Technol. 2023;16(3):1289
Majeed NS, Abdul-Hussein FN. Synthesis, characterization, and studying of biological
activity of some new six-membered compounds derived from Schiff bases. Res J Pharm Technol.
;16(5):2280–6.
Anand SAA, George K, Thomas NS, Kabilan S. Synthesis, characterization and antitumor
activities of some novel thiazinones and thiosemicarbazones derivatives. Phosphorus Sulfur
Silicon Relat Elem. 2020;195(10):821–9.
Higuchi D, Matsubara S, Kadowaki H, Tanaka D, Murakami K. Copper-catalyzed
heterocyclic Recombination of Aziridine and Diazetidine for the Synthesis of Imidazolidine.
Chemistry–A European Journal. 2023;29(43):e202301071.