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Submitted
May 31, 2023
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May 31, 2023
Published
May 31, 2023
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Abstract

Diagnostic and prognostic biomarkers for prostate cancer are few. It has been discovered that it is clinically challenging to discriminate between aggressive and non-aggressive prostate cancer. The aim of this study is to examine the hypothesis that Sox7 may be used as a potential biomarker for prostate cancer diagnosis and prognosis. Sox7 is a transcription factor that is found to play a role in controlling different biological processes throughout embryonic development, such as hemopoiesis, vasculogenesis, and cardiogenesis. It is also believed to be a tumor suppressor in a number of malignancies. Its function in prostate cancer, however, is not well understood. Nuclear and cytoplasmic Sox7 expression has been evaluated by immunohistochemistry using normal (16) and malignant (80) prostate tissues. The immunohistochemical study showed reduced nuclear and cytoplasmic Sox7 expression in prostate cancer compared to normal prostate tissues. This reduction was also associated significantly with increased primary Gleason grade.  This data suggests the possibility that Sox7 may play a key role in prostate tumor formation or aggressiveness, highlighting the need for further study to clarify its role and establish whether it might be used as a prognostic biomarker for prostate cancer.

Keywords

Sox7 IHC Gleason grade Prostate cancer

Article Details

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